Similarly, their mammalian orthologs (Pygo1 and Pygo2, and BCL9 and BCL9-2/B9L, respectively) contribute to efficient β-catenin-mediated transcription in Wnt-stimulated mammalian cells, and in colorectal cancer cell lines with elevated Wnt pathway activity (Adachi et al., 2004; Brembeck et al., 2004; Thompson et al., 2002). Here, BCL9L is linked to colorectal cancer.