Thus, using positional weight matrices (PWMs), which is the most widely used method for recognition of transcription factor binding sites [34,35], we analyzed promoters of genes which were induced by overexpression of c-Myc in alveolar epithelium of our female transgenic mouse model resulting in the development of bronchiolo-alveolar carcinoma (BAC) and papillary adenocarcinoma (PLAC), in order to elucidate the c-Myc transcriptional regulatory network consisting of direct and indirect mechanisms possibly participating in the Myc tumorigenic phenotype. Here, MYC is linked to minimally invasive lung adenocarcinoma.