The analysis of HNF4A, KCNJ11 and RETN polymorphisms did not support their role as T2D risk factors despite sufficient statistical power [see Additional file 3] to detect the effect sizes (1.08, 1.09 and 1.16, respectively) previously established by meta-analysis [21,26,27]. The gene discussed is KCNJ11; the disease is type 2 diabetes mellitus.