A metaanalysis of case-control studies evaluating the potential association between 894G>T eNOS polymorphism and the risk of CAD reached the conclusion that homozygosity for eNOS Asp298 allele was associated with a moderately, though significantly increased risk of CAD [OR = 1.31;95%CI = 1.13–1.51] [31]. The gene discussed is NOS3; the disease is coronary artery disorder.