This was not restricted to Plasmodium 3D7 and the i.p. route of infection because after i.p. or i.v. infection of NODscid/β2m−/− HM with P. falciparum V1/S (n = 10 mice), a multiresistant clinical isolate adapted to in vitro culture, the percentage of success was 100%. The gene discussed is B2M; the disease is infection.