Indeed, infection of adenoviruses harboring calpain-1 (CANP1) into young VSMC dramatically increases calpain-1 activity (Fig. 6B, upper panel) and generates a multiple proteolytic fragment pattern (Fig. 6B, lower panel, 8 mo), similar to old uninfected or CANP-1 infected cells (Fig. 6B, lower panel, 30 mo). The gene discussed is CAPN1; the disease is infection.