CAST and infection: Fig. 7B (upper panel) shows that Ang II treatment increases the migration capacity of young VSMC to the level of untreated old cells. Strikingly, Ci 1 completely abolished the Ang II-/PDGF-BB-induced chemotaxis of both young and old cells. Infection of the adenovirus harboring CAST completely abolished the Ang II-induced VSMC migration increase (Fig. 7B, lower panel).