ADRB2 and obesity due to melanocortin 4 receptor deficiency: In their studies, Dallongeville et al. found that the Gly16Arg and Gln27Glu variants of the β2-AR gene contribute to metabolic syndrome susceptibility in men [4] Large et al. found that the Gln27Glu polymorphism of the β2-AR gene was markedly associated with obesity with a relatively higher risk for obesity and an odds ratio of approximately 10 [9].