When systemic, long-term activation of β-catenin signalling was induced in six week-old SP-C C-RAF BXB mice with lung adenomas via the expression of dominant negative E-cadherin, RT-PCR analysis of tumour cell mRNA revealed the expression of genes (Cdx1, Atoh1) that are normally expressed in the intestine indicating that an epigenetically-driven change in cell fate had occurred [54]. The gene discussed is CDH1; the disease is neoplasm.