In the gliomas with EGFR amplification, we confirmed the overexpression of genes implicated in proliferation (CCNB1, CDK2), extracellular matrix remodeling (PLAT, POSTN), immune response (GBP1), cancer stem cell signaling (IQGAP1) as well as several genes known to be highly expressed in glioblastomas (IGFBP2, CHI3L1, PDPN). This evidence concerns the gene EGFR and central nervous system cancer.