EGFR and central nervous system cancer: They were also enriched in the HC1B gene set (neuronal genes) of Freije et al. In contrast, gliomas with EGFR amplification were enriched in gene sets associated with poor prognosis ("proliferation" and "mesenchymal" gene sets of Phillips et al., and HC2A (enriched in proliferation genes) and HC2B (enriched in extracellular matrix genes) gene sets of Freije et al.)[5,28].