Changes in extracellular matrix and associated proteins have been reported in the metastatic progression of prostate cancer [39], and activation of Focal adhesion kinase through α5β1 integrin/fibronectin has previously been implicated in regulating the invasiveness of prostate cancer cells via activation of phosphatidylinositol-3,4,5-trisphosphate kinase [40]. This evidence concerns the gene FN1 and prostate carcinoma.