In addition to MCL, constitutive NF-κB activity has also been demonstrated in other malignancies including, adult T-cell leukemia, diffuse large B-cell lymphoma, multiple myeloma, Reed-Sternberg cells of Hodgkin lymphoma, pancreatic adenocarcinoma, prostate adenocarcinoma, squamous cell carcinoma of the head and neck, and breast carcinoma [47-53]. The gene discussed is NFKB1; the disease is breast carcinoma.