The mature B cell lymphoma studied here is similar to the non-Hodgkin lymphoma studied by R. Mangues, et al., who demonstrated that L-744,832 could prevent the formation of diffuse large B cell splenic lymphomas in mice that expressed an activated N-Ras oncogene under the MMTV promoter [8]. The gene discussed is NRAS; the disease is B-cell non-Hodgkin lymphoma.