To identify genes that specifically collaborate with deficiency for either p19ARF or p53, the dataset was analyzed in two ways: (a) CISs were determined using all the insertions from the three panels together and CIS-genotype interactions were identified by comparing the number of insertions in a CIS in one genotype versus another, or (b) CISs were determined per panel, and candidate genes of the CISs were compared between panels (see Figure 2A). The gene discussed is TP53; the disease is in situ carcinoma.