CISH and in situ carcinoma: To identify genes that specifically collaborate with deficiency for either p19ARF or p53, the dataset was analyzed in two ways: (a) CISs were determined using all the insertions from the three panels together and CIS-genotype interactions were identified by comparing the number of insertions in a CIS in one genotype versus another, or (b) CISs were determined per panel, and candidate genes of the CISs were compared between panels (see Figure 2A).