IAPP and early-onset autosomal dominant Alzheimer disease: The observations that IAPP fibrils are located at thecellular membrane in the Islets of Langerhans and that this is accompanied byalterations in membrane morphology [1, 4–9] made researchers hypothesize that the membrane mightbe the target of cytotoxic IAPP and that this could cause death of the insulinproducing β-cells, similar to Abeta neurotoxicity in Alzheimer's disease.