RPS16 and infection: It may be that these two processes are fundamentally different since 1) gE mutants with a small-plaque phenotype on MDBK cells have wild-type anterograde spread kinetics in the rat visual system [77], 2) deletion of PRV Us9 has no effect on cell-to-cell spread of infection in epithelial cells, but a dramatic impact on anterograde sorting [11], and 3) gB mutants with a small-plaque phenotype on ST cells [78] have wild-type anterograde neuron-to-cell spread kinetics in our trichamber system (Curanovic and Enquist, unpublished findings).