INS and type 2 diabetes mellitus: Hence the aim of the present investigation was to study both acute and especially long-term effects of palmitate and its interaction with the PPARγ agonist ROZ on the activities of islet NOS isoenzymes in relation to GPR40 and insulin secretion and thus to further elucidate whether the thiazolidinedione drugs would be of possible therapeutic value for the function of the β-cell in dyslipidemic type 2 diabetes.