A few years later, advancement in the study of CPVT was obtained when the autosomal recessive variant of CPVT was linked to chromosome 1 (1p13-p21) and established that the disease gene is encoding for cardiac calsequestrin (CASQ2), another protein strictly implicated in the control of intracellular calcium [25]. The gene discussed is CASQ2; the disease is catecholaminergic polymorphic ventricular tachycardia.