Intriguingly, our data showed that Gli-1 nuclear expression, Hh signal activation, as well as CXCR4 expression were more important than COX-2 or VEGF expressions in tumour relapse and prognosis after CRT, whereas appropriate postoperative chemotherapy could improve the OS period even after the disease progression associated with COX-2 or VEGF expression. This evidence concerns the gene GLI1 and neoplasm.