BMI1 and neoplasm: Glinsky et al (2005) described the prognostic impact of an 11-gene signature displaying a stem cell-resembling expression profile. Their data indicate the presence of a conserved BMI-1-driven pathway, which is similarly engaged in normal stem cells and in a series of highly malignant human cancers arising from a wide range of organs. Steele et al (2006) used SEREX technology and proved widespread overexpression of BMI-1 protein in different tumour types.