IGHG3 and infection: These isotype patterns and the persistence of the IgG response over several months (Fig.1C) differed therefore from the transient IgM and IgG3 autoreactive responses, for example against anti-nuclear antigens, that have been reported after infection with other bacteria (Fournie et al., 1974) (Marshak-Rothstein, 2006) (Morrison and Ryan, 1979) (Rowley and Jenkin, 1962).