In particular, our analysis of 59 cases, for which clinical information was available, suggests 1) an independent role for high cellularity in predicting reduced OS; 2) a significant correlation of cellularity, mitosis, tumour size, high risk, Ki67 expression, and p27Kip1 expression with RFS; 3) a direct correlation of p27Kip1 loss as well as of Ki67 and Skp2 over expression with high risk; and 4) a significant correlation between Ki67 over expression and OS. This evidence concerns the gene SKP2 and neoplasm.