This led to the validation of 14 GBM-specific events: A2BP1, APPA4, BCAS1, CACNA1G, CALD1, CLTA,CLTB, DYNC1I2, KCNC2, NF1, RTN4, SNCB, TNC and TPD52L2. Moreover, our expression profiling analysis indicated that there were relatively few GBM-specific changes for splicing regulators. The gene discussed is RTN4; the disease is glioblastoma.