Previous studies have examined the value of biomarkers such as carcinoembryonic antigen, CA 15-3, MMP-2, MMP-9, tissue polypeptide antigen (TPA), tissue polypeptide-specific antigen (TPS), EGFR, and HER-2/neu in predicting response to NAC for breast cancer [33-36]. This evidence concerns the gene MMP2 and breast cancer.