(1) with atopic dermatitis (s-IgE > 5000 IU/ml, n = 11);(2) with inhalant allergy (200 < s-IgE < 2 000 IU/ml,n = 10); and (3) non-allergic (s- IgE < 100 IU/ml, n = 10). The gene discussed is IGHE; the disease is allergic disease.