IGFBP3 and breast cancer: After further adjustment for age at menarche, number of full-term pregnancies, age at first full-term pregnancy, lactation, family history of breast cancer, number of breast biopsies, education, past use of oral contraceptives, past use of hormone replacement therapy, and height, these correlations were all slightly stronger, and the borderline negative correlation between absolute density and fragmented IGFBP-3 levels became statistically significant.