No association of age at menarche, number of full-term pregnancies, age at first full-term pregnancy, lactation, family history of breast cancer, number of breast biopsies, education, past use of oral contraceptives, past use of hormone replacement therapy, or height was observed with intact, fragmented, and total IGFBP-3 levels (data not shown). This evidence concerns the gene IGFBP3 and breast cancer.