IGFBP3 and breast cancer: This notion was examined by Rinaldi and colleagues [15] in a population of young women, and their results suggested that high levels of functional IGFBP-3, which are composed of intact IGFBP-3 and some fragments of IGFBP-3, could be associated with a reduction of breast cancer risk (odds ratio [OR] = 0.54) whereas high levels of total IGFBP-3 could be associated with an increased risk of breast cancer (OR = 1.47).