Although the role of iNOS in atherosclerosis remains to be defined, genetic deficiency in iNOS has been reported to result reduce atherosclerosis in apolipoprotein E-deficient mice [51] and that chronic treatment of iNOS inhibitors has been shown to limit progression of preexisting atherosclerosis in hypercholesterolaemic rabbits [52]. The gene discussed is NOS2; the disease is atherosclerosis.