Univariate qualitative assessments of RA did not reveal a large variation, and quantitative assessment of anti-cyclic citrullinated protein antibodies (anti-CCP), showed a non-normal distribution, although anti-CCP has been considered a better predictor of erosive outcome compared to the rheumatoid factor (RF) IgM [1-4]. The gene discussed is CD40LG; the disease is rheumatoid arthritis.