The antisense mRNA of the PDGF-B chain, tyrosine kinase inhibitor genistein and STI-571, selective Na+/H+ exchange inhibitor cariporide, dominant-negative soluble PDGFR-β and selective PDGFR tyrosine kinase inhibitor AG1295 have been confirmed to reduce HSCs proliferation and attenuate hepatic fibrosis (13–19). Here, PDGFRB is linked to Hepatic fibrosis.