MBP and asphyxia: This model mimics someof the features of perinatal asphyxia, a major cause of immediate and delayedbrain damage in the newborn [47, 48], and is characterized by early oxidative stress,delayed behavioral deficits, and alteration in myelin formation, as indicatedby the strong reduction of myelin basic protein (MBP) expression (Figure 2(b)).Whether PPAR-γ over-expression is part of an adaptive response to the hypoxic condition aimedat restoring myelin formation or is part of an aberrant program leading behavioralimpairment remain to be established.