The mechanisms of how PPAR-γ agonists induce neuroprotection by blockingneuroinflammation is not fully understood and further information on themolecular details of PPAR-γ in neuroinflammatory pathways will providecrucial insights on the role of PPAR-γ in ALS and other neurodegenerativediseases. This evidence concerns the gene PPARG and amyotrophic lateral sclerosis.