Theactivation or inactivation of PPAR-γ could provide a viable and promisingapproach to understand the mechanism of neuroinflammation in ALS (Figure 1(b)).Since neuroinflammatory pathway hasbecome one of the hallmarks of ALS [29, 33, 34], therefore, blockage of neuroinflammationis of great interest because of the potential efficacy in ALS patients. Here, PPARG is linked to amyotrophic lateral sclerosis.