In response to hypoxia, tumor cellsturn on the angiogenic signaling cascade by secreting various potent angiogenicmediators, such as VEGF, PDGF, bFGFs, angiopoetins, HGF, fibronectin, andheparanase that in turn activate endothelial cells of preexisting capillariesto produce MMPs for the collapse of ECM [39]. This evidence concerns the gene VEGFA and neoplasm.