As shown in Figure 7A, in the absence of Dox the iKO mice had high cholesterol levels similar to that of the KO mice; in the presence of Dox, the iKO showed normal cholesterol levels, demonstrating that inducible expression of ApoE can lead to the reversion of the KO phenotype of hypercholesterolemia. The gene discussed is APOE; the disease is Hypercholesterolemia.