The CTLA-4 variant G allele was associated with an increased RA risk among women in the NHS cohort (multivariable dominant model OR = 1.92 [95% CI = 1.10 to 3.35]), but not in the NHSII cohort or pooled results (multivariable dominant model OR = 1.27 [95% CI = 0.88 to 1.84]; the OR was similar [1.29, 95% CI = 0.54 to 3.08] in a random effects meta-analytically pooled dominant model). This evidence concerns the gene CTLA4 and rheumatoid arthritis.