CALR and peeling skin syndrome: Primary Sjögren syndrome (pSS) is a chronic, slowly progressive, inflammatory, autoimmune disease that is characterised by lymphocytic infiltration of the exocrine glands (which reduces or eliminates glandular secretion) and marked B-lymphocytic cell hyper-reactivity, which initially is manifested by a variety of serum autoantibodies, including those against Ro (SSA) and La (SSB), and rheumatoid factor (RF) [1-4].