CFH and breast carcinoma: For example, BRCA1, a well-known susceptibility gene for breast cancer, and CFH, a susceptibility gene for age-related macular degeneration identified in one of the first published GWASs, are each strongly associated with an eSNP (p = 9.73 × 10−17 for BRCA1 and p = 6.94 × 10−22 for CFH) that falls within 1Mb of the corresponding structural gene (Table S3).