This same subnetwork also included genes like Tgfbr2, Pparg, Lpl, Ppm1l, and Alox5ap, all of which have been previously identified and validated as being associated with traits related to obesity, diabetes, cholesterol levels, and cardiovascular disease [25,31–33]. This evidence concerns the gene TGFBR2 and obesity due to melanocortin 4 receptor deficiency.