Not only was the expression of this gene in the HLC strongly associated with the T1D SNP at this locus, but it was observed to operate in a part of the molecular network that is significantly enriched for genes associated with T1D (like HLA-DRB1), whereas the gene inferred as the most likely susceptibility gene at that locus (ERBB3) [15] was not supported by any of our experimental data. This evidence concerns the gene HLA-DRB1 and type 1 diabetes mellitus.