A quantitative image analysis of brain tissues stained with anti-GFAP and anti-CD45 antibodies indicated that reduction of amyloid plaques in the brains of immune 3xTg-AD mice led to less astrocytosis (P<0.05) and microglial activation (P<0.001), respectively (Figure 9A, B). The gene discussed is GFAP; the disease is amyloidosis.