Polymorphisms of predicted genes (LOC646279, ORrs1256517 = 1.44 [1.03–2.02], P = 0.03; LOC387761, ORrs7480010 = 1.32 [1.01–1.72], P = 0.04), SLC30A8 (ORrs13266634 = 0.76 [0.59–0.97], P = 0.03), MMP26 (ORrs2499953 = 2.45 [1.19–5.04], P = 0.01) and CXCR4 (ORrs932206 = 0.75 [0.57–0.97], P = 0.03) were more prevalent in T2D subjects than in NGT individuals. This evidence concerns the gene MMP26 and type 2 diabetes mellitus.