Polymorphisms of CDKAL1, CDKN2A/2B and IGFBP2 were all associated with T2D (ORrs7756992 = 1.30 [1.19–1.42], P = 2.3×10−9; ORrs10811661 = 0.74 [0.66–0.82], P = 3.5×10−8; and ORrs1470579 = 1.17 [1.07–1.27], P = 0.0003), respectively) (Table 1). This evidence concerns the gene IGFBP2 and type 2 diabetes mellitus.