ATXN1 and glioblastoma: The activation of p38MAPK was detected in cultured mammalian cells of different origins (glioblastoma, fibroblasts and cells of neural lineage) and more importantly in cerebellar Purkinje neurons of transgenic mice expressing the neuropathogenic ataxin-1 cDNA at the age of onset of pathology (Figure 6 and [65]).