The expression of SPARC is variable in different cancers, and its role in tumorigenesis appears complex and not well defined (Wewer et al, 1988; Bellahcene and Castronovo, 1995; Ledda et al, 1997; Said and Motamed, 2005; Tai et al, 2005; DiMartino et al, 2006; Rodriguez-Jimenez et al, 2007). This evidence concerns the gene SPARC and cancer.