TRPC6 is also expressed in epithelial human prostatic cancer cells and the Ca2+-entry via this channel mediates the activation of calcineurin, which in turn induces proliferation via its downstream NFAT (nuclear factor of activated T-cells) transcription factors, which are necessary and sufficient for the induction of prostatic cancer cell proliferation [31]. The gene discussed is TRPC6; the disease is prostate carcinoma.