The total gametocyte density produced during infection was significantly lower in mice with IL-10R blockade, regardless of parasite genotype (Figure 4A and 4B; treatment: F1,60 = 8.8, P = 0.004, clone: F7,60 = 3.85, P = 0.002, treatment × clone: F7,60 = 0.47, P = 0.85). Here, IL10RA is linked to infection.