In keeping with the notion that the extracellular matrix in tumor differs from that in normal tissue [22] glypican-1, laminin alpha 3, tenascin C, versican, as well as different types of collagens (collagen typeI-alpha2, typeIII-alpha1, typeV-alpha1, typeXIII-alpha1 and typeXV-alpha1) and thrombospondin-2, were expressed at higher levels by HOC-EC than by HA-EC (Table 3A). This evidence concerns the gene GPC1 and neoplasm.