Therefore it is possible that CD40-induced Nf-κB activation could ultimately, via induction of Bcl-XL expression and via decoy activity and further Nf-κB activation by cFLIPp43, keep the culprit autoaggressive Th40 cells resistant to death in autoimmunity and further allow expansion of this T cell subset. This evidence concerns the gene CD40 and Autoimmunity.