Both stable G9a-KD clones of the breast cancer cell line MCF7 and the lung cancer cell line H1299 also showed an increased number of chromosomes compared to control cells (MCF7-control vs MCF7-G9a-KD, 60 chromosomes vs 98 chromosomes; H1299-control vs H1299-G9a-KD, 72 chromosomes vs 104 chromosomes; Figure S1). The gene discussed is EHMT2; the disease is breast carcinoma.