In the group with residual cancer, two other gene sets showed enrichment: the ER-associated gene list (FDR q = 0.03, P = 0.04) (Figure 3c and Supplementary Figure 2c) and the mutant p53 gene signature (FDR q = 0.0019, P = 0.07) (Figure 3d and Supplementary Figure 2d). This evidence concerns the gene TP53 and cancer.