CXCR4 and neoplasm: Supporting such in vitro data, our clinicopathological study revealed that CXCR4 expression was significantly positive in CRCs with a high tumour stage and LN metastasis, and patients with CXCR4-positive CRCs showed a significantly worse outcome than those in whom CRCs were negative, suggesting that CXCR4 is a significant prognostic marker in CRC patients.