In fact, the intracellular trafficking of Ku protein to extranuclear sites has been suggested to play important role in numerous non-DNA repair Ku-associated functions [7,13] Importantly, the localization of Ku to the membranes of MM cells following sCD40L treatment leads to increased adhesion to bone marrow stromal cells and interneukin-6 (IL-6) production [12]. Here, IL6 is linked to Miyoshi myopathy.