The selection criteria and data requests provided eleven studies of nine Caucasian asthma populations for our analyses (Table 1) including data from 1,267 pedigrees (n = 5,832) for asthma (80.2% of pedigrees available in the public domain or following request, missing 249 [19] and 65 pedigrees [20]), 989 pedigrees (n = 4,294) for BHR (79.9% of available, missing 249 pedigrees [19]), 1,093 pedigrees (n = 4,746) for SPT (81.5% of available, missing 249 pedigrees [19]) and 729 pedigrees (n = 3,224) for total IgE (65.9% of available, missing 249 [19], and 129 pedigrees [21]). The gene discussed is IGHE; the disease is asthma.