ORMDL3 and asthma: 4/6 regions containing the positionally cloned asthma susceptibility genes i.e. ADAM33 (20p13[7]), PHF11 (13q14.3 [29]), DPP10 (2q14.1 [27]), HLAG (6p21.3 [26]), GPRA (7p14.3 [30]), IL1RN (2q13 [28]) and the recently reported gene ORMDL3 (17q12-q21[24]) were identified by the GSMA approach, ADAM33 (p(OR) = 0.005), DPP10 and IL1RN (p(OR) = 0.007) and less significantly HLA-G (p(SR) = 0.039) and GRPA (p(OR) = 0.031).