Analysis of asthma and atopy quantitative traits identified significant evidence for relatively few chromosomal regions as containing susceptibility gene(s) using the most stringent genome-wide criteria i.e. BHR (6p22.3-p21.1), total IgE (5q11.2-q14.3 and 6pter-p22.3) and positive allergen skin prick test (3p22.1-q22.1, 17p12-q24.3). Here, IGHE is linked to asthma.