In the present study, we examined the extents of involvement of EGF family members in RA pathology by investigating the expression of seven major EGF-like growth factors, namely EGF, AREG, EREG, transforming growth factor α(TGFα), heparin-binding EGF-like growth factor (HB-EGF), betacellulin (BTC) and neuregulin-1 (NRG1), in synovial tissues and mononuclear cells isolated from bone marrow and venous blood. Here, HBEGF is linked to rheumatoid arthritis.