A significant association, at modified FDR levels, between the APOE ε4 allele and AD was detected in AD vs. C (p < 0.0001; α = 0.0082), ADm vs. Cm (p < 0.001; α = 0.0077), and ADf vs. C female (Cf; p < 0.0001; α = 0.0081) comparisons. This evidence concerns the gene APOE and Alzheimer disease.