APOE and Alzheimer disease: The significant decrease in risk of AD observed in ε4-positive males with 1 or 2 lhcgr2 C-alleles lends support to the possibility that lhcgr2-dependent alternative splicing of LHCGR pre-mRNA leads to isoforms of LHCGR that are functionally distinct (see below), or that lhcgr2 is part of an intron-derived microRNA (miRNA) capable of regulating APOE mRNA translation (see below).