APOE and Alzheimer disease: We took great care to ensure that any associations with AD observed in LHB were not the result of linkage with APOE. The only instance of significant LD between an LHB locus and APOE alone was found in the ADf and total AD groups (lhb3, p < 0.0001 for both groups; α = 0.0081 and α = 0.0082, respectively).