Both the 'ε4 dosage' and 'ε4 positive' models of APOE genotype were associated with AD at marginally to highly significant levels in AD vs. C (p < 0.0001; α = 0.0082), ADm vs. Cm (ε4 dosage: p = 0.003; ε4 positive: p = 0.007; α = 0.0077), and ADf vs. Cf (p < 0.0001; α = 0.0081). Here, APOE is linked to Alzheimer disease.