This suggests: (1) a non-random force, such as selection, is driving the non-random association of LQ-insert alleles with specific LHB haplotypes in the North American Caucasian population – i.e., certain variants of LHB may be better suited to the LQ-insert variant of LHCGR; (2) given the extent of LD between lhcgr1 and LHB loci in C and AD samples, instances of significant LD between lhcgr1 and LHB loci in AD samples are not indicative of AD-associated interactions. Here, LHB is linked to Alzheimer disease.